Improving access to endogenous DNA in ancient bones and teeth – University of Copenhagen

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17 June 2015

Improving access to endogenous DNA in ancient bones and teeth

RECOVERING DNA

Poor DNA preservation is the most limiting factor in ancient genomic research. In a paper in Scientific Reports researchers from CGG demonstrate on 14 ancient teeth that by targeting the outer layer of the roots they obtain up to 14 times more endogenous DNA than when using the inner dentine. Their presented methods are likely to increase the proportion of ancient samples that are suitable for genome-scale characterization.

Damgaard PB, Margaryan A, Schroeder H, Orlando L, Willerslev E, Allentoft ME. Improving access to endogenous DNA in ancient bones and teeth. Scientific Reports 5, Article no. 11184, doi:10.1038/srep11184. 17. June 2015