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Background info: Ludovic Orlando

Ludovic Orlando is a former student from the Ecole Normale Superieure of Lyon (ENS, 1996-2000), ie. one of the top-5 French universities. First trained as a molecular biologist, he got more recently interested in computational biology and programming.

As a PhD student (2000-2003), he mainly worked on ancient DNA, with special interest in the population genetics of cave bears and the phylogenetics of woolly rhinos. He joined the phylogenomics laboratory (CNRS EA 3781) for a year, before he was recruited as a permanent assistant professor at the ENS. He taught and performed research at the ENS between 2005 and 2010.

In addition to his own line of research, he developed fruitful international collaborations with Svante Paabo (MPI-EVA, Leipzig, Germany), Alan Cooper (ACAD, Adelaide, Australia) and Anders Gotherstrom (Dept of Evolutionary Biology, Uppsala, Sweden).

Since April 2010, he is leading one research group at the Centre for Geogenetics in Copenhagen. His group develops integrative approaches in ancient DNA research, promoting the field of palaeomics by merging together biochemistry, molecular biology, genomics and computational biology. It benefits from strong connections with Eske Willerslev and Tom Gilbert's research groups.

Contact

Dr. Ludovic Orlando, associate professor (lektor).

Email: orlando.ludovic@gmail.com, Lorlando@snm.ku.dk

Ph: +45 3532 1231

International workshops

SMBE 2012, Dublin, 23-26 June 2012. We co-organize with Tom Gilbert a full session on paleogenomics (Paleogenomics: from fossils to genomes).

Summer school on Palaeogenomics. 17-21 October 2011, Cargese, Corsica

Recent Invited Seminars

March 22nd 2012. Horse paleogenomics: From fossils to genomes. Firenze, Italy.

January 14th 2012. International Plant and Animal Genome XX. TBA. San Diego, US.

December 6th 2011. Ancient DNA. Panum Institute (Population studies and Bio-banks course), Copenhagen, Denmark.

November 9th 2011. Symposium for Biotech Research. Ancient genomes in the next-next generation sequencing era - the case of horse domestication. Copenhagen, Denmark.

October 17th-19th 2011. CNRS RTP Paleogenomics summer school. Serial coalescent: basics, methods and power; Third gen- sequencing of ancient DNA templates: what is different from 2nd gen?; BWA mapping: evaluating different strategies for 2nd and 2rd gen sequencing. Cargese, France.

November 4th 2011. Think Alternative: fossils as unconventional sources of genomic data. Vienna, Austria.

July 28th 2011. True single molecule sequencing of ancient genomes. SMBE meeting, Kyoto, Japan.

Ancient DNA datasets and methods. INQUA congress, 21-27 July 2011, Bern, Switzerland 

July 25th 2011. Palaeogenomics and true single molecule sequencing. INQUA meeting, Bern, Switzerland.

May 24th 2011. TBA. European Research Council, Brussels

April 18th 2011. Ancient DNA genomics. Washington DC, National Museum of Natural History. Next Generation Sequencing: Transformative Technology for Biodiversity Science. Host: Pr. Robert Fleischer (download program in pdf)

February 9th 2011. Ancient DNA: telling something new about the past. Aarhus University, Bioinformatics Research Centre. Host: Dr. Thomas Bataillon

December 8th 2010. Ancient DNA: from molecules to genomes and populations. Paris, Institut Pasteur. Host: Dr. Lluis Quintana-Murci

December 7th 2010. The 1001 genomes and human evolution: a tale from ancient DNA. Paris, Institut Pasteur. Host: Dr. Odile Oziez-Kalogeropoulos.

Selected Publications

Mourier T, Ho S, Gilbert MTP, Willerslev E, Orlando L. 2012: Statistical guidelines for detecting past population shifts using ancient DNA. Mol Biol Evol, in press (doi: 10.1093/molbev/mss094).

Orlando et al. 2011. True single-molecule DNA sequencing of a Pleistocene horse bone. Genome Res. 2011, 21:1705-19

Ginolhac et al. 2011: mapDamage: testing for damage patterns in ancient DNA sequences. Bioinformatics 2011 27:2153-5

Campos PF et al. 2010. Ancient DNA analyses exclude humans as the driving force behind late Pleistocene musk ox (Ovibos moschatus) population dynamics. PNAS 107:5675-80

Rasmussen M et al. 2010. Ancient human genome sequence of an extinct Palaeo-Eskimo. Nature 463:757-62

Orlando L et al. 2009. Revising the recent evolutionary history of equids using ancient DNA. PNAS 106:21754-9

Depaulis F et al. 2009. Using classical population genetics tools with heterochroneous data: time matters! PLoS One 4:e5541.5

Orlando L et al. 2008. DNA from extinct giant lemurs links archaeolemurids to extant indriids. BMC Evol Biol 8:121.6

Valdiosera CE et al. 2008. Surprising migration and population size dynamics in ancient Iberian brown bears (Ursus arctos). PNAS 105:5123-8.7

Krause J et al. 2007. Neanderthals in central Asia and Siberia. Nature 449:902-4

Orlando L, et al. 2006. Revisiting Neandertal diversity with a 100,000 year old mtDNA sequence. Curr Biol 16:R400-2